Stephen C Pflugfelder Selected Research

Corneal Diseases (Corneal Disease)

1/2022	IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse.
12/2011	Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture.
11/2011	Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye.
2/2010	Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice.
1/2003	Anti-inflammatory therapy of dry eye.

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Stephen C Pflugfelder Research Topics

Disease

79	Dry Eye Syndromes (Dry Eye Syndrome) 01/2022 - 01/2002
35	Inflammation (Inflammations) 04/2022 - 10/2003
7	Keratoconjunctivitis Sicca 12/2020 - 10/2003
7	Keratitis 12/2020 - 03/2003
7	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 11/2020 - 10/2005
6	Cataract (Cataracts) 10/2021 - 10/2003
6	Blepharitis 09/2019 - 05/2009
6	Burns 03/2017 - 02/2015
5	Corneal Diseases (Corneal Disease) 01/2022 - 01/2003
5	Infections 01/2020 - 10/2003
5	Glaucoma 09/2019 - 03/2014
4	Keratoconus 09/2019 - 12/2002
4	Keratoconjunctivitis 09/2019 - 05/2009
3	Conjunctival Diseases 01/2021 - 10/2004
3	Disease Progression 01/2020 - 03/2003
3	Wounds and Injuries (Trauma) 11/2017 - 01/2015
3	Metaplasia 12/2013 - 06/2007
2	Dysbiosis 10/2019 - 04/2016
2	Stevens-Johnson Syndrome (Lyell's Syndrome) 01/2016 - 01/2016
2	Corneal Perforation 07/2015 - 08/2005
2	Dacryocystitis (Dacryoadenitis) 03/2015 - 11/2012
1	AIDS-Related Complex (ARC) 01/2022
1	Meibomian Gland Dysfunction 01/2021
1	Retinal Detachment (Retinal Detachments) 09/2019

Drug/Important Bio-Agent (IBA)

23	CytokinesIBA 10/2021 - 02/2004
13	Matrix Metalloproteinases (MMPs)IBA 11/2016 - 10/2004
9	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2020 - 02/2004
7	Fluorescein (Funduscein)FDA LinkGeneric 01/2021 - 06/2003
7	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2004
7	InterferonsIBA 01/2016 - 10/2005
6	Interferon-gamma (Interferon, gamma)IBA 11/2020 - 06/2007
5	Interleukin-17 (Interleukin 17)IBA 01/2022 - 06/2010
5	ChemokinesIBA 11/2020 - 04/2006
5	Anti-Bacterial Agents (Antibiotics)IBA 10/2019 - 11/2010
5	Ophthalmic Solutions (Eye Drops)IBA 01/2019 - 08/2010
5	AlkaliesIBA 03/2017 - 07/2015
5	Doxycycline (Periostat)FDA LinkGeneric 01/2016 - 07/2006
5	EmulsionsIBA 12/2010 - 02/2004
4	Coloring Agents (Dyes)IBA 01/2021 - 02/2010
4	Lubricant Eye Drops (Artificial Tears)IBA 01/2019 - 01/2003
4	IntegrinsIBA 01/2017 - 01/2015
4	LigandsIBA 01/2017 - 09/2011
4	Messenger RNA (mRNA)IBA 11/2016 - 08/2006
4	Dexamethasone (Maxidex)FDA LinkGeneric 11/2016 - 09/2015
3	Butyrates (Butyrate)IBA 04/2022 - 03/2017
3	InterleukinsIBA 01/2021 - 10/2005
3	Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA 01/2018 - 01/2016
3	AntigensIBA 01/2018 - 10/2005
3	lifitegrastIBA 01/2018 - 01/2016
3	Peptide Hydrolases (Proteases)FDA Link 01/2016 - 02/2004
3	Azithromycin (Zithromax)FDA LinkGeneric 10/2015 - 08/2010
3	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2015 - 12/2011
3	Mitogen-Activated Protein KinasesIBA 09/2006 - 12/2004
2	ProdrugsIBA 01/2022 - 11/2012
2	Sirolimus (Rapamycin)FDA Link 11/2020 - 11/2020
2	Transforming Growth Factor beta (TGF-beta)IBA 11/2020 - 09/2010
2	LipopolysaccharidesIBA 10/2019 - 01/2016
2	InflammasomesIBA 06/2017 - 03/2017
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2017 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 11/2016 - 06/2010
2	Pharmaceutical PreparationsIBA 01/2016 - 10/2007
2	MucinsIBA 01/2016 - 03/2014
2	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2014 - 09/2006
2	Loteprednol Etabonate (Alrex)FDA Link 09/2014 - 09/2004
2	Interleukin-13IBA 12/2013 - 10/2005
2	Biological ProductsIBA 12/2013 - 11/2011
2	Scopolamine (Hyoscine)FDA Link 04/2012 - 01/2005
2	AutoantibodiesIBA 04/2012 - 10/2004
2	Thymic Stromal LymphopoietinIBA 12/2011 - 06/2010
2	Transforming Growth Factor beta2IBA 06/2010 - 01/2008
2	Interleukin-1 (Interleukin 1)IBA 08/2008 - 01/2002
2	Cholinergic Agents (Cholinergics)IBA 06/2007 - 01/2005
2	SaltsIBA 09/2006 - 12/2002
2	Methylprednisolone FDA LinkGeneric 09/2006 - 07/2006
2	Phosphotransferases (Kinase)IBA 09/2006 - 12/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2005 - 12/2004
1	Nicotinic AgonistsIBA 01/2022
1	Cholinergic ReceptorsIBA 01/2022
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2022
1	tributyrinIBA 01/2022
1	RetinoidsIBA 01/2021
1	Chemokine CCL5IBA 01/2021
1	Interleukin-12 (IL 12)IBA 01/2021
1	Nerve Growth Factor (NGF)IBA 12/2020
1	Interleukin-9 (Interleukin 9)IBA 11/2020
1	Calcineurin InhibitorsIBA 11/2020
1	voclosporinIBA 11/2020
1	Sodium Chloride FDA LinkGeneric 01/2020
1	Free RadicalsIBA 01/2020
1	TrehaloseIBA 01/2020
1	cenegerminIBA 01/2020
1	dupilumabIBA 09/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019

Therapy/Procedure

27	Therapeutics 12/2020 - 01/2003
6	Laser In Situ Keratomileusis (LASIK) 07/2010 - 03/2003
4	Contact Lenses 11/2017 - 12/2002
3	Refractive Surgical Procedures 10/2021 - 10/2003
2	Fecal Microbiota Transplantation 02/2018 - 01/2018
2	Prostheses and Implants (Prosthesis) 04/2011 - 12/2010
1	Surgical Instruments (Clip) 01/2021